Every area of the human body has a unique ecology and therefore a unique microbiome. The gut microbiome is spoken about frequently, but less commonly discussed are the specific microbiomes contained in other areas such as the skin, the lungs, the mouth, and even the vagina. The vaginal microbiome is abundant in Lactobacillus species, as they contribute heavily to the production of lactic acid. The lactic acid maintains a pH of 4, which if elevated, is a risk for vaginal microbiome challenges. Urogenital concerns are experienced frequently by women, and the most common interventions do little to address the state of vaginal ecology, and therefore, repeated challenges are often experienced. Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 have been studied and proven to support healthy vaginal ecology and promote microbial balance.